KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
18.18
Human Site:
S275
Identified Species:
33.33
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
S275
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
P322
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
S275
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
K
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
S275
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
P340
T
K
V
L
Q
E
E
P
P
L
L
P
G
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S291
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Chicken
Gallus gallus
Q90891
398
44059
P328
D
Y
I
V
N
E
P
P
P
K
L
P
N
G
V
Frog
Xenopus laevis
Q07192
446
50082
P372
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S302
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
P268
R
Q
V
V
E
D
S
P
P
R
L
P
E
G
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
L290
V
S
G
D
P
P
I
L
H
P
D
S
D
D
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
P291
E
A
I
V
D
Q
P
P
P
A
L
P
S
G
N
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
P584
S
A
I
V
D
G
P
P
P
R
L
P
S
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
40
N.A.
100
N.A.
100
33.3
N.A.
93.3
40
40
93.3
N.A.
46.6
N.A.
6.6
N.A.
P-Site Similarity:
100
60
N.A.
100
N.A.
100
53.3
N.A.
100
53.3
53.3
100
N.A.
66.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
0
0
8
0
0
39
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
8
16
8
8
0
0
0
8
0
8
54
0
% D
% Glu:
8
0
0
0
47
62
8
0
0
0
0
0
8
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
0
0
16
0
0
0
0
0
0
8
31
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% H
% Ile:
0
0
31
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
39
8
0
0
8
0
0
0
0
16
0
0
0
0
31
% K
% Leu:
0
0
0
8
0
0
0
8
0
8
93
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
16
0
0
0
0
0
0
0
16
0
8
% N
% Pro:
0
0
0
0
8
8
70
54
93
8
0
85
0
0
0
% P
% Gln:
0
54
0
0
8
8
0
0
0
47
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
16
0
0
0
0
16
% R
% Ser:
8
8
0
0
0
0
8
39
0
0
0
16
24
8
0
% S
% Thr:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
8
0
62
85
0
0
0
0
0
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _